Ziwig Endotest®

A major innovation to reduce time to diagnosis!

Healthcare professional: be notified when Ziwig Endotest® is available

What is Ziwig Endotest® ?

Ziwig Endotest® is a secured solution with superior performance to all currently available diagnostic tools1-5 (laparoscopy, MRI, pelvic ultrasound). It has been validated by one of the largest clinical studies in the world*, in collaboration with 6 French centers specialized in endometriosis. Ziwig Endotest® has CE rating.

Non-invasive and easy-to-use test, Ziwig Endotest® reliably detects endometriosis but also removes any doubts in the most complex cases.

*See the Science page

Possibly allows to put an end to the diagnostic errancy (reducing the average time to diagnosis from 8 years to a few days) but also to improve the overall care of endometriosis by:

  • Opening the way to early treatment of endometriosis

  • Allowing to slow down or even stop the aggravation of pain and other symptoms

  • Optimizing the care of infertility

  • Limiting the deterioration of patients’ quality of life

Reliable and fast.

Ziwig Endotest® is the possibility of knowing, within a few days and with a reliability close to 100% (sensitivity of 97%, specificity of 100%, diagnostic accuracy (AUC) of 98%)³, if your patients are suffering from endometriosis.

Simple to use
but based on cutting edge technology.

Ziwig Endotest® requires a simple saliva sample. The diagnosis is made in the laboratory. It relies on Next-generation Sequencing of micro RNA present in saliva and on the use of artificial intelligence to process the very large volume of data generated.

A unique technology accessible to all healthcare professionals.

No matter where you are located, in a large metropolis or in the countryside, Ziwig Endotest® allows you to obtain a simple, reliable and fast diagnosis for your patients.

Shorten wandering and restore hope!

Women affected by endometriosis endure an average of 8 years⁷ of diagnostic errancy and see approximately 10 doctors⁸ before being diagnosed.

Put an end to your patients’ uncertainty by providing them with a clear and reliable diagnosis.

Conceived for all cases of endometriosis, including the most complex.

Ziwig Endotest® makes it possible to confirm or eliminate the diagnosis of endometriosis with a high reliability and to distinguish endometriosis from other pathologies with a similar sympthomatology1-5. It is particularly indicated in complex cases where medical imaging remains uncertain.

A large clinical study conducted in collaboration with 5 general hospitals.

A study involving 1000 patients to evaluate the value of miRNAs for the diagnosis of endometriosis.

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In partnership with
the patient association Endomind.

"The arrival of Endotest® Diagnostic is a radical change for all women who suffer from pelvic pain. Getting a reliable diagnosis in a few days with a simple saliva sample is a real revolution for them and their medical care."

Nathalie ClaryPresident of the association Endomind

A premium

Ziwig Endotest® is performed with CE rated in-vitro diagnostic medical devices.

Ziwig applies the ISO 13485 standard for quality management systems.

We respect the RGPD obligations and the recommendations of the e-health charter recommended by the Ministry of Health.

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Ziwig Endotest®, a major breakthrough for women’s health.

Healthcare professional: be notified when Ziwig Endotest® is available

This page is exclusively intended for healthcare professionals.

Ziwig Endotest® is an in vitro diagnostic device reserved exclusively for professional use for the diagnosis of endometriosis on salivary samples.
Ziwig Endotest® is an innovative diagnostic method based on the analysis of salivary miRNAs and the identification of phenotypic profiles characteristic of endometriosis identified by NGS (Next Generation Sequencing) method and modeled by AI.
Read carefully the information provided with Ziwig Endotest®. Manufacturer: Ziwig. Update: MM/2022.

1- Machine learning algorithms as new screening approach for patients with endometriosis.
Bendifallah S & al. Sci Rep. 2022 Jan 12;12(1):639. doi: 10.1038/s41598-021-04637-2.
2 – Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Serum Micro-RNA Expression.
Dabi Y & al. Diagnostics (Basel). 2022 Jan 12;12(1):175. doi: 10.3390/diagnostics12010175.
3 – Salivary MicroRNA Signature for Diagnosis of Endometriosis.
Bendifallah & al. J Clin Med. 2022 Jan 26;11(3):612. doi: 10.3390/jcm11030612.
4 – MicroRNome analysis generates a blood-based signature for endometriosis.
Bendifallah S & al. Sci Rep. 2022 Mar 8;12(1):4051. doi: 10.1038/s41598-022-07771-7.
5 – Endometriosis Associated-miRNome Analysis of Blood Samples: A Prospective Study
Bendifallah S & al. Diagnostics. 2022; 12(5):1150.
6 – A Bioinformatics Approach to MicroRNA-Sequencing Analysis Based on Human Saliva Samples of Patients with Endometriosis.
Bendifallah S & al. Int. J. Mol. 2022, 23, 8045.
7 – https://solidarites-sante.gouv.fr/soins-et-maladies/prises-en-charge-specialisees/endometriose
8 – Omar Kanj. Evaluation économique de la prise en charge de l’endométriose. Economies et finances. Université Clermont Auvergne, 2017. Français.

Find all our scientific publications here.